This website is for UK Healthcare Professionals only

This promotional material is intended for UK Healthcare Professionals only.
BOTOX® (botulinum toxin type A) Prescribing Information and adverse event reporting information can be found below.

Reduce the impact of neurogenic detrusor overactivity (NDO) on your patients' lives

BOTOX®: significant and sustained improvements for NDO patients5,6,7                         

Reduce the impact of NDO symptoms on your patients’ lives.

Study context: Pooled analysis of two double-blind, placebo controlled, randomised phase 3 clinical studies, in 691 patients with urinary incontinence due to NDO. To assess the efficacy, safety and effects on quality of life of BOTOX® patients with NDO. Mean baseline weekly frequency of UI: 32.4 BOTOX® and 31.5 Placebo.5



BOTOX® increases bladder capacity in patients with urinary incontinence due to NDO5,6,7

Adapted from BOTOX® Summary of Product Characteristics.5

Study context: Two double-blind, placebo controlled, randomised phase 3 clinical studies, in 691 patients with urinary incontinence due to NDO. Pooled pivotal study data.5

Bladder capacity was defined as maximum cystometric capacity and is shown as mean change from baseline.


I-QoL: Incontinence-quality of life; NDO: neurogenic detrusor overactivity; UI: urinary incontinence.

 

References

  1. Allergan. Data on file. INT/0423/2016
  2. Aurora S K, Winner P et al. Onabotulinum toxin A for treatment of chronic migraine: pooled analyses of the 56-week PREEMPT clinical program. Headache. 2011;51(9):1358-1373
  3. Blumenfeld A M, Stark R J et al. Long-term study of the efficacy and safety of Onabotulinum toxin A for the prevention of chronic migraine: COMPEL study. J Headache Pain. 2018;19(1):13
  4. AbbVie Data on file. Approval Dates for BOTOX® in UK. REF-112127.
  5. BOTOX® Summary of Product Characteristics. Available at: www.medicines.org.uk.
  6. Ginsberg D, et al. J Urol. 2012;187:2131-2139.
  7. Cruz F, et al. Eur Urol. 2011;60:742-750.

 

References

  1. Allergan. Data on file. INT/0423/2016
  2. Aurora S K, Winner P et al. Onabotulinum toxin A for treatment of chronic migraine: pooled analyses of the 56-week PREEMPT clinical program. Headache. 2011;51(9):1358-1373
  3. Blumenfeld A M, Stark R J et al. Long-term study of the efficacy and safety of Onabotulinum toxin A for the prevention of chronic migraine: COMPEL study. J Headache Pain. 2018;19(1):13
  4. AbbVie Data on file. Approval Dates for BOTOX® in UK. REF-112127.
  5. BOTOX® Summary of Product Characteristics. Available at: www.medicines.org.uk.
  6. Ginsberg D, et al. J Urol. 2012;187:2131-2139.
  7. Cruz F, et al. Eur Urol. 2011;60:742-750.

Please refer to the BOTOX® Summary of Product Characteristics for further information on adverse events, contraindications and special warnings and precautions for use. The BOTOX® Summary of Product Characteristics can be found here

By clicking the link above you will leave the AbbVie Pro website and be taken to the eMC PI portal website.

Adverse events should be reported. Reporting forms and information can be found at https://yellowcard.mhra.gov.uk/

Adverse events should also be reported to AbbVie on GBPV@abbvie.com 

 

Date of preparation: June 2025. UK-BUO-250045.