In Chronic migraine, real experience for the real world^1,5,7,10-12

For full prescribing information please refer to the Summary of Product Characteristics available at www.medicines.ie

INDICATION¹

BOTOX^® is indicated for symptom relief in adults fulfilling criteria for chronic migraine (headaches on ≥15 days per month of which at least 8 days with migraine) in patients who have responded inadequately or are intolerant of prophylactic migraine medications.

References:

1. BOTOX^® Summary of Product Characteristics; available on www.medicines.ie.

2. World Health Organization. The global burden of disease: 2004 update. https://apps.who.int/iris/bitstream/handle/10665/43942/9789241563710_eng.pdf

3. Adams AM et al. Cephalalgia. 2015;35(7):563-578.

4. Buse DC et al. Headache. 2019;59(1):32-45.

5. Aurora SK et al. Headache. 2011;51(9):1358-1373.

6. Dodick DW et al. Headache. 2010;50(6):921-936.

7. Whitcup SM. In: Whitcup SM, eds. Botulinum Toxin Therapy. Springer Nature Switzerland AG; 2021:chap 1. Handbook of Experimental Pharmacology; vol 263. ISBN 978-3-030-66305-6.

8. Negro A et al. J Headache Pain. 2016;17(1).

9. Blumenfeld AM et al. J Neurol Neurosurg Psychiatry. 2019;90(3):353-360.

10. Blumenfeld AM et al. J Headache Pain. 2018;19(1):13.

11. Cheng F et al. Expert Opin Drug Saf. 2021;20(11):1275-1289.

12. Whitcup SM et al. Ann N Y Acad Sci. 2014;1329:67-80.