Additional prespecified endpoint,
not controlled for multiplicity.

*Bio-naïve defined as without prior biologic failure and includes patients who had previous exposure to biologics but did not experience treatment failure.
Bio-failure refers to prior treatment failure to at least 1 biologic therapy.

Corticosteroid-free clinical remission per aMs: clinical remission per aMs at Week 52 and corticosteroid-free for ≥90 days immediately preceding Week 52 among patients who achieved clinical remission at the end of the induction treatment.1

aMs: adapted Mayo score; ESS: endoscopic subscore; QD: once daily; RBS: rectal bleeding subscore; SFS: stool frequency subscore.

REFERENCES
 

  1. RINVOQ Summary of Product Characteristics.
  2. Danese S, Vermeire S, Zhou W, et al. Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double-blind, randomised trials. Lancet. 2022;399(10341):2113–2128.