This promotional material is intended for UK Healthcare Professionals (HCPs) experienced in the diagnosis and management of Parkinson’s disease only. Adverse event reporting can be found below
DUODOPA (levodopa/carbidopa intestinal gel)
DUODOPA
(levodopa/carbidopa intestinal gel)
PRODUODOPA (foslevodopa/foscarbidopa solution for infusion)
PRODUODOPA
(foslevodopa/foscarbidopa solution for infusion)
A look at Complex/Advanced Parkinson's disease
DUODOPA (levodopa/carbidopa intestinal gel) is indicated for the treatment of advanced levodopa-responsive Parkinson's disease with severe motor fluctuations and hyperkinesia or dyskinesia when available combinations of Parkinson medicinal products have not given satisfactory results.1
PRODUODOPA (foslevodopa/foscarbidopa solution for infusion) is indicated for the treatment of advanced levodopa-responsive Parkinson's disease with severe motor fluctuations and hyperkinesia or dyskinesia when available combinations of Parkinson medicinal products have not given satisfactory results.2,3
Levodopa may activate malignant melanoma, so PRODUODOPA and DUODOPA should not be used in patients with suspicious undiagnosed skin lesions or a history of melanoma.1-3
The following are fictional case studies, developed solely for educational and illustrative purposes.
Using '5 or 2 or 1' in practice
Could a non-oral therapy be an option for Richard?
Richard experiences uncontrolled PD. His dosing frequency has exceeded 5 doses per day, so he's reached a threshold to be considered for a non-oral therapy.
Meet Richard
62 years old
Onset of PD at 56
Married to Lena, has four grown children
and 12 grandchildren
Former tax advisor
Symptomology
'ON' time during his waking day limited to 4 hours
1 hour of 'OFF' time
Non-troublesome dyskinesia
History
Has tried most anti-Parkinson's oral medications available
PD not well controlled
8 doses of oral levodopa a day
Impact of motor symptoms
Trouble dressing
Fatigue
Difficulty chewing and swallowing
Could a non-oral therapy be an option for Carol?
As well as her 4 doses of levodopa, Carol takes a COMT inhibitor. However, control is increasingly wearing-off and she experiences at least 3 hours of 'OFF' time every day. She's reached a threshold to be considered for a non-oral therapy.
Meet Carol
59 years old
Onset of PD at 53
Lives with husband, has two grown daughters
Former professional artist
Symptomology
Increasing problem with wearing-off
Experiences non-troublesome dyskinesias
3 hours of 'OFF' time a day
History
Good response to oral levodopa
PD not well controlled
4 doses of oral levodopa a day
COMT inhibitor
Impact of motor symptoms
Can no longer paint/draw
Trouble getting out of bed
Fatigue
Could a non-oral therapy be an option for David?
David's PD is not well controlled. The dose of levodopa has been increased, but there are still unpredictable fluctuations of motor symptoms. David experiences 3 hours of troublesome dyskinesia every day
Meet David
75 years old
Onset of PD at 66
Loves to go fishing with wife Jenny
Symptomology
Increased levodopa diminished 'OFF' time
Unpredictable fluctuations of motor symptoms
Prescribed amantadine
3 hours of troublesome dyskinesia
History
Responding to MAOBi
PD not well controlled
Impact of motor symptoms
Dressing
Moving around the house
Struggling to continue fishing
COMT=catechol-O-methyltransferase; MAOBi=monoamine oxidase B inhibitor.
Learn about the progression of PD
Stay connected
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Please only fill out your details if you are a UK registered healthcare professional.
1. DUODOPA (levodopa/carbidopa intestinal gel) SmPC.
2. PRODUODOPA (foslevodopa/foscarbidopa solution for infusion) GB SmPC.
3. PRODUODOPA (foslevodopa/foscarbidopa solution for infusion) NI SmPC.
Adverse events should be reported. Reporting forms and information can be found at yellowcard.mhra.gov.uk or via the MHRA Yellow Card app, available in the Google Play or Apple App Stores.
Adverse events should also be reported to AbbVie on [email protected]
UK-PRODD-230068. Date of preparation: December 2023
