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The Patient Experience: Quality of Life

Migraine is associated with a substantial personal burden, resulting from headache-related disability, a high rate of comorbidities, reduced health-related quality of life and a concomitant financial burden.5,6 Migraine can also affect work productivity, interpersonal dynamics and psychological health and wellbeing, both for the patient and for their family.7 Unsurprisingly, it has been shown that this impact is greatest in families of people with chronic migraine.7

The personal burden of chronic migraine

data for patients with chronic migraine.

The societal burden of chronic migraine

The economic burden of the disease reflects the higher disease severity and associated comorbidities of chronic migraine compared with episodic migraine.10

Common comorbidities in patients with chronic migraine8,13

of patients with chronic migraine have comorbid depression (n=1,476)

of patients with chronic migraine have generalised anxiety disorder (n=1,476)

It is common for patients to experience anticipatory anxiety of their next migraine attack during a pain-free period. This can also encourage overuse of analgesic medication.11

Chronic migraine is a complex neurological disease requiring appropriate effective management - including treatment or referrals to improve patient outcomes2,14,15

CM: chronic migraine; COPD: chronic obstructive pulmonary disease; PTSD: post-traumatic stress disorder.

BOTOX® (botulinum toxin type A) is indicated for the prophylaxis of headaches in adults with chronic migraine (headaches on at least 15 days per month of which at least 8 days are with migraine).16



  1. Allergan. Data on file. INT/0423/2016
  2. Aurora S K, Winner P et al. OnabotulinumtoxinA for treatment of chronic migraine: pooled analyses of the 56-week PREEMPT clinical program. Headache 2011;51(9):1358-1373
  3. Blumenfeld A M, Stark R J et al. Long-term study of the efficacy and safety of OnabotulinumtoxinA for the prevention of chronic migraine: COMPEL study. J Headache Pain 2018;19(1):13
  4. Allergan. Data on file. 014
  5. Buse D C, Scher A I et al. Impact of migraine on the family: perspectives of people with migraine and their spouse/domestic partner in the CaMEO study. Mayo Clin Proc 2016;91(5):596-611
  6. Steiner T J, Stovner L J et al. Migraine is first cause of disability in under 50s: will health politicians now take notice? J Headache Pain 2018;19(1):17
  7. Buse D C, Fanning K M et al. Life with migraine: effects on relationships, career, and finances from the Chronic migraine epidemiology and Outcomes (CaMEO) study. Headache 2019;59(8):1286-1299
  8. Buse D C, Manack A et al. Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. J Neurol Neurosurg Psychiatry 2010;81(4):428-432
  9. Buse D C, Rains J C et al. Sleep disorders among people with migraine: results from the Chronic Migraine Epidemiology and Outcomes (CaMEO) study. Headache 2019;59(1):32-45
  10. Adams A M, Serrano D et al. The impact of chronic migraine: the Chronic Migraine Epidemiology and Outcomes (CaMEO) study methods and baseline results. Cephalalgia 2015;35(7):563-578
  11. Agosti R. Migraine burden of disease: from the patient's experience to a socio-economic view. Headache 2018;58 Suppl 1:17-32
  12. Bloudek L M, Stokes M et al. Cost of healthcare for patients with migraine in five European countries: results from the International Burden of Migraine Study (IBMS). J Headache Pain 2012;13(5):361-378
  13. Escher C M, Paracka L et al. Botulinum toxin in the management of chronic migraine: clinical evidence and experience. Ther Adv Neurol Disord 2017;10(2):127-135
  14. International Headache Society (IHS). International classification of headache disorders (3rd edition) guidelines. Available at: Accessed April 2022
  15. Weatherall M W. The diagnosis and treatment of chronic migraine. Ther Adv Chronic Dis 2015;6(3):115-123
  16. BOTOX® Summary of Product Characteristics. Available at: Accessed April 2022

Please refer to the BOTOX® Summary of Product Characteristics for further information on adverse events, contraindications and special warnings and precautions for use.


Adverse events should be reported. Reporting forms and information can be found at

Adverse events should also be reported to AbbVie on [email protected] 


Date of preparation: April 2022. UK-BCM-220069.