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    • VENCLYXTO® OFFERS PATIENTS WITH CLL A CHANCE TO

      BREAK FREE with longer progression-free survival

      VENCLYXTO in combination with obinutuzumab is indicated for the treatment of adult patients with previously untreated chronic lymphocytic leukemia (CLL).

      VENCLYXTO in combination with rituximab is indicated for the treatment of adult patients with CLL who have received at least one prior therapy.

      [Placeholder for safety statement, per local regulations]

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      *Reduced risk of progression or death vs O+Clb (HR=0.35; 95% CI: 0.23–0.53 [P<0.0001]) Median follow-up of 28 months. Median PFS not reached in either arm.

      Reduced risk of progression or death vs BR (HR=0.17; 95% CI: 0.11–0.25 [P<0.0001]). Median follow-up of 23.8 months. Median PFS not reached with VEN+R vs 17 months (15.5–21.6) with BR.

      VENCLYXTO-based regimens now proven in two phase 3 clinical trials, opening treatment possibilities for more patients with CLL

      *Treatment complete after twelve 28-day cycles.1

      Treatment complete after 5-week dose-titration period and twenty-four 28-day cycles.1

      Secondary endpoint. Deep response as indicated by CR or MRD negativity.

      §Sustained off-treatment response based on 2-year (CLL14) and 4-year (MURANO) updated efficacy analyses.1,3

      CLL=chronic lymphocytic leukemia; 1L=first line; O+Clb=obinutuzumab + chlorambucil; HR=hazard ratio; CI=confidence interval; PFS=progression-free survival; BR=bendamustine + rituximab; VEN+R=VENCLYXTO + rituximab; VEN+O=VENCLYXTO + obinutuzumab; 2L+=second line + later lines of therapy; CR=complete remission; CRi=complete remission with incomplete marrow recovery; INV=investigator; MRD=minimal residual disease; PB=peripheral blood; ITT=intent to treat; 1° EP=primary endpoint; NR=not reached; OS=overall survival; AR=adverse reaction; TLS=tumor lysis syndrome.

      References: 1. VENCLYXTO Summary of Product Characteristics. Ludwigshafen, Germany: AbbVie Deutschland GmbH & Co. KG. 2. Fischer K, Al-Sawaf O, Bahlo J, et al. Venetoclax and obinutuzumab in patients with CLL and coexisting conditions. N Engl J Med. 2019;380(23):2225-2236. 3. Seymour JF, Kipps TJ, Eichhorst B, et al. Time-limited venetoclaxrituximab in relapsed/refractory chronic lymphocytic leukaemia: first presentation of 4-year data from the MURANO study. Presented at: XVIII International Workshop on CLL (iwCLL); September 20-23, 2019; Edinburgh, Scotland. Poster #2266.