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    • This Webiste is For Healthcare Professionals Practicing in Saudi Arabia Only

      RINVOQ preferentially inhibits signalling by JAK1 or JAK1/3 with functional selectivity over cytokine receptors that signal via pairs of JAK2. Atopic dermatitis (AD) is driven by pro-inflammatory cytokines that transduce signals via the JAK1 pathway. Inhibiting JAK1 with RINVOQ reduces the signaling of many mediators which drive the signs and symptoms of AD.1

      Learn why RINVOQ may be an appropriate treatment option for your moderate to severe AD patients.

       

       

       




      Rheumatoid arthritis

      RINVOQ (upadacitinib) is indicated for the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate. RINVOQ may be used as monotherapy or in combination with methotrexate or other nonbiologic DMARDS.

      Atopic Dermatitis

      RINVOQ is indicated for the treatment of adults and adolescents 12 years and older with moderate to severe atopic dermatitis who are candidates for systemic therapy

      AD: atopic dermatitis; ; RA: rheumatoid arthritis.

       

       

      See the RINVOQ Summary of Product Characteristics for full Prescribing Information.

      REFERENCES

       
      1. RINVOQ Saudi  Summary of Product Characteristics – [July , 2021].
      2. Guttman-Yassky E, Teixeira H, Simpson E, et al. Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials. Lancet. 2021; DOI: 10.1016/S0140-6736.
      3. Simpson EL, Papp KA, Blauvelt A, et al. Efficacy and Safety of Upadacitinib in Patients With Atopic Dermatitis: Results Through Week 52 From Replicate,Phase 3, Randomized, Double-Blind, Placebo-Controlled Studies: Measure Up 1 and Measure Up 2. Presented at the 2021 Dermatology EducationFoundation (DEF) Essential Resource Meeting (DERM2021), August 5–8, 2021, Las Vegas NV, USA.
      4. Blauvelt, A, et al. Upadacitinib Versus Dupilumab in Adults with Moderate-to-Severe Atopic Dermatitis: Analysis of the Heads Up Phase 3 Trial. International Society of Atopic Dermatitis (ISAD) 2021 Annual Meeting: Abstract PT29.
      5. European Medicines Agency. RINVOQ EPAR: Public Assessment Report. Available at: https://www.ema.europa.eu/en/medicines/human/ EPAR/rinvoq. Accessed April 2021.
      6. Reich K, Teixeira HD, Bruin-Weller, et al. Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2021; DOI:10.1016/ S0140-6736(21)00589-4.
      7. Rubbert-Roth A, Enejosa J, Pangan AL, et al. Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis. N Engl J Med. 2020;383(16):1511–1521.
      8. Kameda H, Takeuchi T, Yamaoka K, et al. Efficacy and safety of upadacitinib in Japanese patients with rheumatoid arthritis (SELECT-SUNRISE): a placebo-controlled phase IIb/III study. Rheumatology (Oxford). 2020;59(11):3303–3313.
      9. Xiaofeng Zeng, Dongbao Zhao, Sebastiao Radominski. Efficacy and Safety of Upadacitinib in Patients From China, Brazil, and South Korea With Rheumatoid Arthritis Who Have Had Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs. Abstract presented at the European Congress of Rheumatology, 3–6 June 2020. Abstract SAT0160.
      10. ClinicalTrials.gov. A Study to Evaluate Safety of Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis (Rising Up). Available at: https://clinicaltrials.gov/ct2/show/NCT03661138 Accessed March 2021.

      Imprtant Safety Information:

      SERIOUS INFECTIONS

      Patients treated with RINVOQ are at increased risk for developing serious infections that may  lead to hospitalization or death

      Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids.

      If a serious infection develops, interrupt RINVOQ until the infection is controlled.

      Reported infections include:

      •Active tuberculosis, which may present with pulmonary or extrapulmonary disease. Patients should be tested for latent tuberculosis before RINVOQ use and during therapy. Treatment for latent infection should be considered prior to RINVOQ use.

      •Invasive fungal infections, including cryptococcosis and pneumocystosis.

      •Bacterial, viral, including herpes zoster, and other infections due to opportunistic pathogens.

      The risks and benefits of treatment with RINVOQ should be carefully considered prior to initiating therapy in patients with chronic or recurrent infection.

      Patients should be closely monitored for the development of signs and symptoms of infection during and after treatment with RINVOQ, including the possible development of tuberculosis in patients who tested negative for latent tuberculosis infection prior to initiating therapy 

      Warnings and Precautions .

      MALIGNANCIES

      Lymphoma and other malignancies have been observed in patients treated with RINVOQ [see Warnings and Precautions .

      THROMBOSIS

      Thrombosis, including deep venous thrombosis, pulmonary embolism, and arterial thrombosis have occurred in patients treated with Janus kinase inhibitors used to treat inflammatory conditions. Many of these adverse events were serious and some resulted in death. Consider the risks and benefits prior to treating patients who may be at increased risk. 

      ▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions.


      For Adverse Events Reporting:

      Email: PV.MEA@abbvie.com


      Hotline number: +966 55 828 2010

      SA-UPAD-210005 - Oct 2021