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    • The study evaluated 2 doses of upadacitinib, 15 mg and 30 mg QD. The results presented here are for RINVOQ (upadacitinib) 15 mg once daily, which is the approved dose for Rheumatoid Arthritis.

      SELECT-NEXT: Study design

      A Phase 3 study investigating the efficacy and safety of RINVOQ + csDMARDs compared to placebo + csDMARDs in patients with moderate to severe RA and an inadequate response to csDMARDs1

      RINVOQ 15 mg + csDMARD(s) vs placebo + csDMARD(s) at Week 12 for DAS28 (CRP) <3.2 or ACR20

      Adverse events, serious adverse events, adverse events of special interest (e.g., serious infections, opportunistic infections, MACEs, VTEs, malignancies)

      ACR: American College of Rheumatology; ACR20: improvement of at least 20% in the American College of Rheumatology core criteria; csDMARD: conventional synthetic disease-modifying antirheumatic drug; DAS28 (CRP): disease activity score with 28 joint count (C-reactive protein); MACE: major adverse cardiovascular event; MTX: methotrexate; QD: once daily; VTE: venous thromboembolic event.

      RINVOQ 15 mg: Efficacy with csDMARDS after inadequate response to csDMARDS 

      SELECT-NEXT: Low disease activity and remission at Week 12 in patients with an inadequate response to csDMARDs (NRI)1,2

      *P≤0.001 vs placebo + csDMARD(s) 

      csDMARD: conventional synthetic disease-modifying anti-rheumatic drug; DAS28 (CRP): disease activity score with 28 joint count (C-reactive protein); NRI: nonresponder imputation.


      SELECT-NEXT: Adverse events through 12 weeks of treatment1

      *One case of congestive cardiac failure, one cardiovascular procedure.


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      1. Burmester GR, Kremer JM, Van den Bosch F, et al. Safety and efficacy of upadacitinib in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (SELECT-NEXT): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2018;391(10139):2503‍-‍2512. doi:10.1016/S0140-6736(18)31115-2
      2. RINVOQ SPC avsnitt 5.1, sist oppdatert 21.05.2022.