Instructions for taking VENCLYXTO®


Click on Getting Started on VENCLYXTO and VENCLYXTO Patient Booklet below to learn about how VENCLYXTO® works,

and how and when to take it.





Instructions for taking VENCLYXTO®

When administering VENCLYXTO®, advise patients as follows:

Be adequately hydrated every day when taking VENCLYXTO® to reduce the risk of TLS.

Adequate hydration is particularly important 2 days before and on the day of the first dose, and every time the dose is increased. The recommended volume is 1.5–2 L of water (6–8 glasses) each day.

Take VENCLYXTO® orally once daily with a meal and water at approximately the same time each day.

Swallow the VENCLYXTO® tablets whole.
The tablets should not be chewed, crushed, or broken before swallowing.

In case of a missed dose, advise patients as follows:

If a patient misses a dose within 8 hours from the time it is usually taken:
The patient should take the missed dose right away and take the next dose as usual.

If a patient misses a dose by more than 8 hours:
The patient should not take the missed dose and should take the next dose at the usual time.

If a patient vomits following dosing:
No additional dose should be taken that day. The next prescribed dose should be taken at the usual time the next day.

CLL=chronic lymphocytic leukaemia; 2L+=second line + later lines of therapy; HR=hazard ratio; CI=confidence interval; PFS=progression-free survival; BR=bendamustine + rituximab; VEN+R=VENCLYXTO® + rituximab; TLS=tumour lysis syndrome.

▼This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions via HPRA. Website:

Reference: 1. VENCLYXTO® Summary of Product Characteristics, available at 

 IE-VNCCLL-220036 | Date of preparation: July 2022