Glossary
ADR – adverse drug reaction
Advanced therapies – there may come a time when tablets, capsules or patches are no longer working so well to control symptoms. Additional options for the treatment of APD include apomorphine (a subcutaneous injection or infusion of a dopamine agonist), levodopa/carbidopa intestinal gel (inserted into the stomach by a tube) or deep brain stimulation (fine wires inserted into the brain with surgery)
AE – adverse event
AOR – adjusted odds ratio
Complex PD – complex Parkinson’s disease, also known as advanced Parkinson’s disease
DBS – deep brain stimulation
GI tract – gastrointestinal tract
HES – Hospital Episode Statistics. A database containing details of all admissions, outpatient appointments and A & E attendances at NHS hospitals
HRQoL – health-related quality of life
NHSE – National Health Service England
NJ – nasojejunal
NMSS – non-motor symptom scale
‘Off’ time – periods of the day when the medication is not working well, causing worsening of Parkinsonian symptoms. ‘Wearing-off’ episodes may occur predictably and gradually, or they may emerge suddenly and unexpectedly. ‘Wearing-off’ periods may be improved with appropriate changes in the medication regimen
‘On’ time – periods of the day with adequate control of Parkinson's symptoms
‘On’–‘Off’ fluctuations – the cycle between good control of Parkinson’s and periods of worsening symptoms
OR – odds ratio
PD – Parkinson’s disease
PEG-J – percutaneous endoscopic gastro-jejunostomy
Pts – patients
UDysRS - the Unified Dyskinesia Rating Scale has established metric properties that can measure all aspects of dyskinesia with a comprehensive score2
References
- Duodopa (levodopa/carbidopa intestinal gel) Summary of Product Characteristics. Available at: www.medicines.org.uk.
- Alvarez EF, et al. Presented at the MDS Virtual Congress, 12–16 September 2020:867.
Adverse events should be reported. Reporting forms and information can be found at yellowcard.mhra.gov.uk.
Adverse events should also be reported to AbbVie on [email protected]
UK-DUOD-210081. Date of preparation: May 2021.