What is the Challenge with Pediatric Ulcerative Colitis?

  • Incidence from 1 to 4 per 100,000 per year in most North American and European countries1
  • Estimated prevalence of 21.6 per 100,0002

Adapted from : Kayal M and Shah S. J Clin Med. 20203
aOver 3–4 years;
bCumulative 5-year reported rate.

Patients’ First surgery is Earlier in Childhood-onset than in Adult-onset UC6

STRIDE-II: Time-Based Treat-to-Target Recommendations for UC in Pediatrics7

*Time to achieving the target vary based on therapy and mechanism;
#The cutoff value of fecal calprotectin is dependent on the desired outcome. Lower thresholds (e.g. <100 μg/g) have been proposed for reflecting deep healing (both endoscopic and transmural healing) or histological healing;
Assessment of endoscopic healing can be achieved by sigmoidoscopy or colonoscopy. When not feasible, alternatives in CD can be capsule endoscopy or balloon enteroscopy.

  1. Turner D, et al. J Pediatr Gastroenterol Nutr. 2018;67(2):257–291;
  2. Ye Y, et al. Inflamm Bowel Dis. 2020;26(4):619–625;
  3. Kayal M and Shah S. J Clin Med 2020;9(1):94;
  4. Van Limbergen J, et al. Gastroenterology 2008;135(4):1114–22;
  5. Rinawi Fe al. J Pediatr Gastroenterol Nutr 2017;65(4):410–5;
  6. Van Limbergen J, et al. Gastroenterology 2008; 135:1114–1122.;
  7. Turner D, et al. Gastroenterology. 2021; S0016-5085(20)35572-4.

AP: Abdominal pain;
CRP: C-reactive protein,
FC: Faecal calprotectin;
HBI: Harvey-Bradshaw index;
HRQoL: Health-related quality of life;
PeDUC: Pediatric ulcerative colitis;
PRO: Patient-reported outcomes;
SES-CD: Simplified endoscopic score for Crohn’s disease;
SF: Stool frequency.
QoL: Quality Of Life
UCEIS: Ulcerative Colitis Endoscopic Index of Severity

AbbVie sa/nv Vault: BE-IMM-210048 (v2.0) - August 2022