Immunology:
Our other therapeutic areas

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      • What is the Challenge with Pediatric Ulcerative Colitis?

      • Incidence from 1 to 4 per 100,000 per year in most North American and European countries1
      • Estimated prevalence of 21.6 per 100,0002
      uc-what-is-the-challenge

      Adapted from : Kayal M and Shah S. J Clin Med. 20203
      aOver 3–4 years;
      bCumulative 5-year reported rate.

      Patients’ First surgery is Earlier in Childhood-onset than in Adult-onset UC6

      uc-what-is-the-challenge

      STRIDE-II: Time-Based Treat-to-Target Recommendations for UC in Pediatrics7

      *Time to achieving the target vary based on therapy and mechanism;
      #The cutoff value of fecal calprotectin is dependent on the desired outcome. Lower thresholds (e.g. <100 μg/g) have been proposed for reflecting deep healing (both endoscopic and transmural healing) or histological healing;
      †Assessment of endoscopic healing can be achieved by sigmoidoscopy or colonoscopy. When not feasible, alternatives in CD can be capsule endoscopy or balloon enteroscopy.

      1. Turner D, et al. J Pediatr Gastroenterol Nutr. 2018;67(2):257–291;
      2. Ye Y, et al. Inflamm Bowel Dis. 2020;26(4):619–625;
      3. Kayal M and Shah S. J Clin Med 2020;9(1):94;
      4. Van Limbergen J, et al. Gastroenterology 2008;135(4):1114–22;
      5. Rinawi Fe al. J Pediatr Gastroenterol Nutr 2017;65(4):410–5;
      6. Van Limbergen J, et al. Gastroenterology 2008; 135:1114–1122.;
      7. Turner D, et al. Gastroenterology. 2021; S0016-5085(20)35572-4.

      AP: Abdominal pain;
      CRP: C-reactive protein,
      FC: Faecal calprotectin;
      HBI: Harvey-Bradshaw index;
      HRQoL: Health-related quality of life;
      PeDUC: Pediatric ulcerative colitis;
      PRO: Patient-reported outcomes;
      SES-CD: Simplified endoscopic score for Crohn’s disease;
      SF: Stool frequency.
      QoL: Quality Of Life
      UCEIS: Ulcerative Colitis Endoscopic Index of Severity

      AbbVie sa/nv Vault: BE-IMM-210048 (v2.0) - August 2022