*Time to achieving the target vary based on therapy and mechanism;
#The cutoff value of fecal calprotectin is dependent on the desired outcome. Lower thresholds (e.g. <100 μg/g) have been proposed for reflecting deep healing (both endoscopic and transmural healing) or histological healing;
†Assessment of endoscopic healing can be achieved by sigmoidoscopy or colonoscopy. When not feasible, alternatives in CD can be capsule endoscopy or balloon enteroscopy.